Stage 2 : Egg Retrieval and Sperm Preparation
A. Egg Retrieval
As the mature follicle is monitored on ultrasound, gonadotrophinis injected and the egg is retrieved after about 34-36 hours later. In most cases, the eggs are retrieved from the patient using a transvaginal technique called transvaginal oocyte retrieval, involving an ultrasound-guided needle piercing the vaginal wall to reach the ovaries.
B. Sperm Preparation
Sperm is prepared for fertilization on the day of egg retrieval, andabstinence 2-3 ahead of sperm preparation is ecommended. Sperm is collected in the container through masturbation, and, depending on the situation, can be collected from the frozen sperm or through a surgical procedure.
Stage 3 : In-Vitro Fertilization and Culture
Upon retrieval of the egg and sperm, they are put on a culture dish containing culture medium for fertilization. In general, it is left for natural fertilization, otherwise intracytoplasmic sperm injection (ICSI) is also opted. The fertilized embryo is cultured for about 3-5 days.
Stage 4 : Embryo Transfer
The fertilized embryo is inserted to the endometrium using a catheter. The locations of the catheter and embryo are checked under abdominal ultrasound. Depending on the age of the patient, conditions of the embryo and number of days of culture, 1-3 embryos are transferred. No anesthesia is required, and the patient can return to normal daily life after taking a rest for about 10 minutes.
Stage 5: Luteal Support
Luteal support begins after egg retrieval. In most cases, progesterone agent or gonadotrophin agent is used, which can be injected, inserted through the vagina or orally administered. Luteal support contributes to the implantation of the embryo and embryogenesis.
IVF – Treatment Program
Price – KRW 8,000,000 ~ 9,000,000 ($6,800~7,600 1cycle)
*Average USA cost – 12,000
(1 cycle, according to Verywell family, 2019)
*Depending on individuals, a method of ovulation stimulation, dose of drugs, injections and test types may be different.
Duration – 25~30 days (1 cycle)